Development of Chip Electrophoresis-Laser Spray Ionization Mass Spectrometry Using Gold Nanoparticles

本研究在纳米喷雾直接集成电泳芯片上研究了金纳米粒子激光喷雾电离质谱（LSIMS）技术的发展。将含金纳米粒子的样品溶液通过输注方式从纳米喷雾中引入质谱检测器。当532 nm的cw激光照射到纳米喷雾的尖端时，在负模式下，MS信号强度增加了12倍。因此，揭示了使用金纳米粒子的硅质谱对阴离子分析物的质谱信号有增强作用。

In this study, development of laser spray ionization-mass spectrometry (LSIMS) using gold nanoparticles was investigated on nanospray directly integrated electrophoresis chips. A sample solution containing gold nanoparticles was introduced from the nanospray to the MS detector by the infusion mode. When a 532-nm CW-laser was irradiated to the tip of the nanospray, 12-fold increase in the MS signal intensity was observed in the negative mode. Therefore, it was revealed that LSI-MS using gold nanoparticles gave the MS signal enhancements for anionic analytes.