Novel roles of CYLD in the molecular pathogenesis of intractable diseases

近年来，肿瘤抑制因子CYLD在各种顽固性疾病的发病机制中发挥着重要作用。在本研究中，我们主要关注cyld相关疾病(1)。肺纤维化，2分。慢性阻塞性肺疾病；揭示CYLD作为一种去泛素酶，通过抑制细胞内tgf - β信号、NF-κB信号等信号调控疾病相关基因表达，参与多种疾病的发生。

Tumor suppressor CYLD has been recently shown to play important roles in the pathogenesis of various intractable diseases. In the present study, we focused on the CYLD-related diseases (1. lung fibrosis, 2. chronic obstructive pulmonary disease, 3. familial amyloidotic polyneuropathy) and revealed that CYLD acted as a deubiquitinase and involved in various diseases by suppressing intracellular signaling, such as TGFβ signal and NF-κB signal to regulate the disease-related gene expression.