A study on oral function of hyposalivation models

液体分泌对毒蕈碱激动剂的反应用小鼠离体下颌骨灌注技术进行了分析。降低体温引起的唾液分泌减少。同时，灌注液渗透压升高导致体液分泌减少。对液体分泌至关重要的通道、受体和转运体的药理抑制也会抑制液体分泌。体外分泌唾液中的离子浓度在不同的模拟模型中存在差异。结果表明，离子浓度分析可能有助于识别导致低盐度的目标。

Fluid secretion in response to muscarinic agonists was analyzed using a mouse ex vivo submandibular perfusion technique. Lowering the temperature from the body temperature induced less salivation. Also, increasing the osmolarity in perfusion solution caused less fluid secretion. Pharmacological inhibition on channels, receptors and transporters crucial for fluid secretion also inhibited fluid secretion. Ion concentrations in secreted ex vivo saliva turned out their ion compositions were different among hyposalivaiton models. The results suggest that ion concentration analysis might work for identifying the target which causes hyposalivation.