Synthesis of Cationic Glycopolymer and Development of Sugar-Coated Polyplex for Gene Delivery Application

我们合成了一种新型的阳离子糖基聚合物，并对其作为基因载体的功能进行了评价。采用精确控制聚合的方法，成功地合成了阳离子单体与含D-甘露糖的乙烯基单体的嵌段共聚物。初步的体外实验为高效阳离子糖共聚物作为基因载体的分子结构提供了关键。

We have performed the synthesis of novel cationic glycopolymer, which is synthetic polymer bearing carbohydrate moieties, and the evaluation of their functions as a gene carrier. Block copolymers of cationic monomer with vinyl monomer bearing D-mannose have been successfully synthesized by means of precisely controlled polymerization. Preliminary in vitro experiment afforded a key for the molecular architecture of the efficient cationic glycopolymer as gene carrier.