Effects of dietary protein on immunological activity and host resistance to fungal infection in mice

为了建立宿主抗真菌的最佳日粮，我们研究了不同日粮蛋白质水平对宿主对病原菌抗性的影响。低蛋白质饲料小鼠的脾脏和肝脏抗真菌活性高于正常蛋白质饲料小鼠。相比之下，高蛋白饮食的小鼠在这些器官中的抗真菌活性降低。本研究结果表明，在营养不良的情况下限制蛋白质摄入有利于宿主对病原菌的抗性，而高蛋白摄入则会损害宿主的抗性。

In an effort to establish the optimum diet for host resistance, we investigated the effect of different dietary protein levels on host resistance to pathogenic fungi. Mice refed low protein diet showed higher antifungal activity in the spleen and liver compared with mice on the normal protein diet. In contrast, mice refed high protein diet showed reduced antifungal activity in these organs. The present results imply that protein restriction without malnutrition could be beneficial to host resistance to pathogeni fungi, but high protein intake impairs host resistance.