Development of nucleophilic cyanation to non-activated alkynes

用非活化炔和氰源催化量的Pd(II)进行了亲核氰化反应。这种在有机金属化学中未见报道的基本转化被命名为氰基聚合，它促进了炔烃的亲电活化，并平滑了来自外部CN源(如TMSCN)的亲核攻击。此外，还发现了具有共轭烯炔单元的烯炔和二烯炔类化合物非常适合于通过环化协议以区域和立体选择性的方式安装CN官能团。

Nucleophilic cyanation has been developed by using catalytic amount of Pd(II) with non-activated alkynes and CN source. This fundamental and non-reported transformation in organometallic chemistry is named as cyanopalladation which promote electrophilic activation of alkynes and smooth nucleophilic attack from external CN source such as TMSCN. Furthermore, enynes and dienynes which have conjugated enyne units have been found for quite suitable substrates to install CN functionality in regio- and stereoselective fashion through cyclization protocol.