Mechanism and physiological role for generation of the carboxyl terminal fragment of the P/Q-type calcium channel

第二代Cav2。1个羧基末端尾（Cav2. 1CT）被认为与脊髓小脑共济失调6型（一种遗传性神经系统疾病）有因果关系。Cav2. 1CT通过全长Cav2的切割产生。1蛋白质。但是Cav2产生的确切机制。1CT及其功能尚不清楚。在本研究中，我试图阐明产生Cav2的机制。全长Cav2的1CT。1蛋白质。此外，我还研究了Cav2的功能作用。1CT在某些体外系统中。因此，以下分子是负责Cav2的蛋白酶的候选分子。1CT生成：半胱天冬酶6、组织蛋白酶L和钙蛋白酶小亚基1，但需要进一步研究得出结论。Cav2.发现CT对细胞有毒，并且Cav2. 1CT具有转录抑制活性

Generation of Cav2. 1 carboxyl terminal tail(Cav2. 1CT) is thought to be causally related to spinocerebellar ataxia type 6, a hereditary neurological disease. Cav2. 1CT is generated by cleavage of the full-length Cav2. 1 protein. But the exact mechanism underlying the generation of Cav2. 1CT and the function of this CT fragment remain to be clarified. In the present study, I have tried to clarify the mechanism to generate the Cav2. 1CT from full-length Cav2. 1 protein. Also, I have studied the functional role of the Cav2. 1CT in some in vitro systems. As a result, the following molecules are candidates for the protease responsible for the Cav2. 1CT generation : caspase 6, cathepsin L, and calpain small subunit 1, but further studies are necessary to conclude this. Cav2. 1CT was found to be toxic to cells and it is possible that Cav2. 1CT possess transcription repressing activity