Novel approach to liver disease from aspect of cellular senescence

这项研究表明，细胞衰老参与了原发性胆汁性肝硬化（PBC）等肝脏疾病的发病机制。PBC中发炎和受损小胆管中的衰老胆管上皮细胞显示趋化因子如CCR2和CX3CL1的表达增加。培养的衰老胆管上皮细胞表现出多种趋化因子的表达增加，并诱导单核细胞和肝星状细胞在共培养中迁移。提示衰老的胆管上皮细胞可能通过调节PBC的微环境而参与胆管周围炎症的加重。

This study revealed that cellular senescence is involved in the pathogenesis of liver diseases such as primary biliary cirrhosis(PBC). Senescent biliary epithelial cells in inflamed and damaged small bile ducts in PBC show increased expression of chemokines such as CCR2 and CX3CL1. Cultured senescent biliary epithelial cells showed increased expression of various chemokines and induced migration of monocytes and hepatic stellate cells in co-culture. These findings suggests that senescent biliary epithelial cells may play a role in augmentation of inflammation around bile ducts by regulating microenvironment in PBC.