Developing early diagnostic markers of neuropathy with collagen disease and establishment of the clinical examination scheduling process

在这项研究中，我们试图开发早期诊断标志物的神经病变与胶原病，并建立临床检查调度程序。我们的研究结果表明，定量感觉测试（QST），激光多普勒血流仪，皮肤活检是最有用的方法来诊断神经病变与胶原病。此外，我们可以挑选出许多蛋白质和肽，这些蛋白质和肽有可能成为疾病的早期诊断标志物。

In this study, we tried to develop early diagnostic markers of neuropathy with collagen disease and establish the clinical examination scheduling process. Our results suggest that quantitative sensory testing(QST), laser-Doppler flowmetry, and skin biopsy are the most useful methods to diagnose the neuropathy with collagen disease. Moreover, we could pick up many proteins and peptides which have the potential to become early diagnostic markers of the disease.