Effect of exposure to xerophilic fungi on the onset and aggravation of mite-induced atopic dermatitis in NC/Nga mice.

我们研究了嗜干真菌曲霉是否会加重NC/Nga小鼠尘螨诱导的特应性皮炎样皮肤病变。曲霉是一种霉菌，常见于卧室或客厅。曲霉提取物局部应用于小鼠皮炎损伤部位，对螨性特应性皮炎影响轻微。但多次皮下注射提取物会增加皮下炎症部位的过敏反应。此外，气管内注射提取物6个月可加重小鼠特应性皮炎。因此，我们认为曲霉可能是特应性皮炎的一个加重因素。

We investigated whether xerophilic fungi, Aspergillus aggravates mite-induced atopic dermatitis-like skin lesion in NC/Nga mice. Aspergillus is a kind of mold and found in a bedroom or living room. The topical application of the extract of Aspregillus on the lesion sites in mice was lightly affected on mite-induced atopic dermatitis. But the multiple subcutaneous injection of the extract led to increased allergic responses in subcutaneous inflammation sites. In addition, intratracheal injection of the extract for six months aggravated the atopic dermatitis in mice. Therefore, it is suggested that Aspergillus can be an aggravating factor for atopic dermatitis.