A cohort study on the effect of vitamin D on fracture and bone mineral density as outcomes of osteoporosis

这项研究的目的是确定维生素D对骨质疏松相关骨参数的预防作用。一项为期五年和六年的队列研究分别在横滨和村松进行。研究对象包括横滨595名年龄在55岁至74岁之间的女性和村松775名年龄在70岁及以上的女性。基线时测定血清25-羟基维生素D(25[OH]D)作为维生素D状态的指标，结果分别是骨密度(BMD)和骨质疏松性骨折。尽管25(OH)D与髋部或腰椎骨密度的五年变化无关，但高的25(OH)D(≧71nmol/L)与较低的骨折风险相关。

The aim of this study was to determine preventive effects of vitamin D on bone parameters in relation to osteoporosis. A five-year and six-year cohort studies were conducted in Yokogoshi and Muramatsu, respectively. Subjects were 595 women aged between 55 and 74 years in Yokogoshi and 775 women aged 70 years and over in Muramatsu. Serum 25-hydroxyvitamin D(25[OH] D) at baseline was measured as an index of vitamin D status, and outcomes were bone mineral density(BMD) and incident osteoporotic fractures, respectively. Although 25(OH) D was not associated a five-year change in BMD of hip or lumbar spine, the high 25(OH) D(≧71 nmol/L) associated with lower risk of fracture.