Effects of early statin treatment on circulating inflammatory biomarkers and progressing stroke.

入选146例缺血性卒中患者，分为他汀组(阿托伐他汀10 mg，每日1次，发病48小时内开始用药)和非他汀组(2周内不用他汀类药物)。早期应用他汀类药物可显著降低入院后14天的血清IL-6水平(p=0.047)和神经功能恶化的频率(p=0.035)。48小时内的他汀类药物治疗可降低IL-6的升高，并可能防止早期神经恶化。

A total of 146 ischemic stroke patients were enrolled and were divided into Statin Group(atorvastatin, 10 mg daily, initiated within 48 hrs after the onset) and Non-Statin Group(statin was not administered for 2 weeks). Early statin treatment significantly lowered the serum levels of IL-6(p=0.047) and frequency of neurological deterioration during 14 days after admission(p=0.035). Statin treatment within 48 hrs decreases IL-6 elevation and may protect against early neurological deterioration.