Role of Mitochondria on Platelet Activation Contributing to the Onset of Acute Myocardial Infarction

血小板在急性心肌梗死的发病中起着至关重要的作用。血小板是一种活跃的细胞，与多个线粒体进行能量代谢。本研究试图阐明线粒体在血小板细胞中对急性心肌梗死发病的作用。线粒体需要氧气来表达其生理功能。高氧动脉血中的血小板比静脉血中的血小板具有更高的血栓形成性。线粒体的数量和定位不受血小板活化的影响。当线粒体功能被阻断时，血小板活化引起的细胞内钙离子浓度循环升高受到抑制。

Platelets play crucial role in the onset of acute myocardial infarction. Platelets are active cells in view of energetic metabolism with several mitochondria. This study attempts to clarify the role of mitochondria in platelet cells for the onset of acute myocardial infarction.Mitochondria need oxygen to express their physiological function. Platelets in arterial blood containing high oxygen concentration have higher thrombogenicity than those in venous blood. The number and localization of mitochondria was not influenced by platelet activation. Cyclic increase in intracellular concentration of calcium ion induced by platelet activation was inhibited when the function of mitochondria was blocked.