Intermittent hypoxia in the progression of diabetic nephropathy and Intermittent hypoxia in the progression of diabetic nephropathy and Role of fatty acid binding protein

由于睡眠呼吸暂停综合征(SAS)可能导致糖尿病或高血压控制不佳，因此SAS可能是糖尿病肾病进展的危险因素。在本研究中，研究了1型糖尿病或高血压模型的遗传模型。小鼠或大鼠被安置在循环氧气室中，并暴露在慢性间歇性低氧(CIH)中，在CIH中，调整氧气和氮气的流速，以实现环境氧气在CIH中从21%到10%的间歇性(10分钟)减少12小时。然而，没有证据表明慢性间歇性低氧与糖尿病或高血压引起的肾脏疾病的恶化有关。

Because sleep apnea syndrome(SAS) may contribute to poor control of diabetes or hypertension, it is possible that SAS is a risk factor for the progression of diabetic nephropathy. In this study, genetic models of type 1 diabetes or hypertension model were examined. The mice or rats were housed within a cycled oxygen chamber and were exposed to chronic intermittent hypoxia(CIH) in which oxygen and nitrogen flow rates were adjusted to achieve episodic(10 miniute) reductions of ambient oxygen from 21% to 10% for CIH for 12 hours. Howerver, it was not demonstrated that chronic intermittent hypoxia was related to the deterioration of kidney disease induced by diabetes or hypertension.