Identifying a novel insulin-like hormone in a patient with fulminant type 1 diabetes using protein-protein interaction methods

在暴发性糖尿病患者中，血糖水平通常难以控制，因为他们的内源性胰岛素分泌从一开始就被耗尽。1例暴发性1型糖尿病患者注射少量外源性胰岛素后血糖控制良好。这种罕见的情况下，我们假设一个未知的胰岛素样激素将存在于这个病人的血液。为了探索这一假说，我们已经进行了初步的实验，蛋白质-蛋白质相互作用，使用人重组胰岛素受体，虽然结果并不预期。

In patients with fulminant diabetes, the blood glucose levels are generally difficult to control because their endogenous insulin secretion are depleted from the onset. A patient with fulminant type 1 diabetes shows excellent glycemic control with small amount of exogenous insulin injection. This rare case leads us to hypothesize that an unknown insulin-like hormone will exist in this patient's blood. To explore this hypothesis, we have performed preliminary experiments of protein-protein interaction using human recombinant insulin receptor, although the results were not expected.