The study of the interactions between muscle and bone/mineral metabolism.

本研究的目的是鉴定肌肉组织中的局部骨化因子和肌肉产生的体液骨合成代谢因子，以阐明肌肉和骨/矿物质代谢之间的相互作用。通过对肌源性细胞和成骨信号增强细胞的综合基因分析，筛选出具有成骨活性的因子。其中，Tmem 119被认为是局部诱导肌肉骨化的因子。另一方面，骨甘氨酸和FAM 5C可能是新的体液性骨合成代谢因子的候选者。我们希望进一步研究这些因素作为骨质疏松症治疗发展的假定靶点。

The aim of our study is the identification of local ossification factors in muscle tissues and humoral bone anabolic factors produced from muscles in order to clarify the interactions between muscle and bone/mineral metabolism. We selected the factors with bone formation activity using the comprehensive gene analysis between muscle-derived cells and ossification signal-enhanced cells. Among them, Tmem119 is expected the factor, which locally induces muscle ossification. On the other hand, osteoglycin and FAM5C may be the candidates of novel humoral bone anabolic factors produced from muscles. We would like to proceed the further study of these factors as the putative targets for the development of the treatment of osteoporosis.