The etiology of food allergy and inflammatory bowel diseases in children inrelation to peptides derived from digested food proteins.

为了研究儿童食物过敏和炎症性肠病（IBD）的病因与消化食物蛋白衍生肽的关系，分析了它们的抗原性；然而，在食物过敏或IBD衍生的血清中没有确认特异性反应。我们还通过芯片、RT-PCR、免疫组化等方法对食物蛋白诱导的直肠炎（FPIP）和IBD的粘膜样本进行了研究，发现CCL11和CXCL13信号对结肠粘膜嗜酸性粒细胞浸润的淋巴样增生在FPIP中起重要作用，而CXCL9和CXCR3是儿童IBD的关键分子。

To investigate the etiology of food allergy and inflammatory bowel diseases(IBD) in children in relation to peptides derived from digested food proteins, their antigenicity was analyzed ; however, no specific reactions were confirmed in serum derived from food allergy or IBD. We have also investigated the mucosal samples taken from food protein-induced proctocolitis(FPIP) and IBD with microarray, RT-PCR, immunohistochemistry and found that the lymphoid hyperplasia with eosinophilic infiltration into the colonic mucosa in response to CCL11 and CXCL13 signaling is important in FPIP while CXCL9 and CXCR3 are the key molecules in pediatric IBD.