assessment of central nervous system immunity in a rat glioma model by USPIO-enhanced magnetic resonance imaging

小胶质细胞在中枢神经系统免疫中具有重要作用。胶质瘤组织的组织病理学研究显示高水平的浸润性小胶质细胞。由于小胶质细胞在胶质瘤的免疫治疗中是一个有吸引力的候选者，因此开发利用磁共振成像监测小胶质细胞功能的方法是必不可少的。我们发现，超小颗粒氧化铁（USPIO）造影剂可以潜在地增强小胶质细胞功能的可视化，尽管需要抑制小胶质细胞外USPIO产生的背景信号强度的技术。

Microglia has an important role in central nervous system immunity. Histopathologic studies of glioma tissue have revealed high levels of infiltrating microglia. Because microglia is an attractive candidate in immnotherapy for glioma, development of the method to monitor microglial function by magnetic resonance imaging is essential. We showed that ultra-small particles of iron oxide (USPIO) contrast agent could potentially enhance visualization of microglial function although the technique to suppress background signal intensity originating from USPIO outside of microglia should be needed.