Prediction of prognosis of hepatocellular carcinoma with use of measurement of methylated CCND2 gene in the blood

本研究的目的是建立一种利用血清中CCND2基因甲基化水平来预测肝细胞癌患者预后的微创系统。(1)我们确定了血清采集和DNA提取的几个条件。(2)我们建立了血清中CCND2基因甲基化特异的定量PCR分析方法。(3)我们证明了血清中CCND2基因甲基化水平与不良专利结局有关。我们以9篇论文的形式报道了相关研究。6)在学术会议上阅读17篇论文

The purpose of this study is to develop a minimally invasive predictive system with use of methylated CCND2 gene in the serum responsible for outcome of patients with hepatocellular carcinoma(HCC).(1) We determined several conditions for serum collection and DNA extraction.(2) We established a quantitative methylation-specific PCR analysis for CCND2 gene in serum.(3) We demonstrated that methylation levels of CCND2 gene in serum were associated with poor outcome of patentsWe reported the relevant research in the form of 9 papers(total of IF=26. 6) and read 17 papers at academic meetings