immune environment in the peritoneal cavity and development of novel immune therapy in ovarian cancer

在这项研究中，我们假设癌细胞主动改变腹膜腔中的免疫环境，以便扩散。通过使用人卵巢癌样品以及小鼠卵巢癌腹膜传播模型，我们深入分析了免疫环境与癌症传播之间的关联。我们发现，PD-L1是一种免疫抑制分子，通过与腹腔中的免疫细胞相遇而表达或诱导。PD-L1的强制表达可促进腹膜播散，而抑制PD-L1则可抑制腹膜播散，提示PD-L1高表达的卵巢癌中，PD-L1可能成为抑制腹膜播散的治疗靶点。

In this study, we hypothesized that cancer cells actively alter immune environment in the peritoneal cavity I order to disseminate. By using human ovarian cancer samples as well as mouse ovarian cancer peritoneal dissemination model, we thoroughly analyzed the association between immune environment and cancer dissemination. We found that PD-L1, an immune suppressive molecule, is expressed or induced by encountering the immune cells in the peritoneal cavity. Forced expression of PD-L1 resulted in the promotion of peritoneal dissemination, while inhibition of PD-L1 inhibited it. These result indicate that, in ovarian cancers with high PD-L1 expression, this molecule could be a therapeutic target to suppress peritoneal dissemination.