Olfactory regenerative medicine by granulocyte-colony stimulating factor

统计分析表明，早期给予G-CSF（粒细胞集落刺激因子）可提高骨髓源性细胞在嗅上皮内的植入率。此外，受体小鼠嗅上皮中发现了绿色荧光蛋白（GFP）和嗅觉标记蛋白（OMP）等双免疫染色细胞，提示骨髓源性细胞作为嗅觉组织的干细胞被移植。因此，嗅觉组织损伤后早期给予G-CSF对骨髓细胞嗅觉再生医学有效。

A statistical analysis demonstrated significantly that the early administration of G-CSF(granulocyte-colony stimulating factor) was appropriate to increase the engraftment rate of bone marrow-derived cells into the olfactory epithelium. Moreover, cells with double-immunostaining for GFP(green fluorescence protein) and OMP(olfactory marker protein) and so on were found in the olfactory epithelium of recipient mice, which suggested that bone marrow-derived cells are engrafted as stem cells of the olfactory tissue. Thus, the early administration of G-CSF after insult to the olfactory tissue is suggested to be effective to olfactory regenerative medicine using bone marrow cells.