P53 and PET羊elated parameters as a prognostic factor of head and neck carcinoma treated by chemoradiation

p53 codon72多态性和p503突变的预后意义除了临床因素外，我们还对接受同步放化疗的局部晚期头颈部鳞状细胞癌患者的人乳头瘤病毒和治疗前PET参数进行前瞻性研究。治疗前PET参数包括SUVmax。SUV平均值和原发性肿瘤的代谢肿瘤体积。多因素分析显示MTV仅为独立的预后因素。低MTV肿瘤患者的总体生存率和喉切除术生存率明显高于高MTV肿瘤患者。

Prognostic significance of p53 codon72 polymorphism, p503 mutations. human papillomavirus, and pretreatment PET parameters, in addition to clinical factors, were prospectively addressed in patients with locoreginally advanced head and neck sqamous cell carcinoma treated by concurrent chemoradiotherapy. Pretreatment PET parameters include SUVmax. SUVmean, and metabolic tumor volume of a primary tumor. Multivariatc analysis revealed that MTV is only an independent prognostic factor. Overall survival as well as laryngectomy survival were significantly better in patients with low MTV tumor than in those with high MTV tumor.