The development and clinical significance of laboratory examination on finger blood volume with light emitting diode during a non-invasive static pressurization

了解动脉粥样硬化性疾病中微血管的病理生理是很重要的，但目前还没有相关的实验室检查。我们开发了一种新的方法，在非侵入性的皮肤静态加压过程中移动手指毛细血管的血液水平，基于发光二极管的血红蛋白吸收来定量测量。用该方法评估的速度压力指数（VPI）具有临床可接受的重复性和变异系数。糖尿病患者的VPI水平明显低于对照组。在这些患者中，VPI水平与肥胖、血脂等几种动脉粥样硬化危险因素显著正相关。睡眠时间较长的糖尿病和高血压患者的VPI水平明显低于睡眠时间充足的患者。这些数据表明，我们所开发的方法可能有助于观察生活方式相关疾病的毛细血管病理生理。进一步的研究是必要的，以建立这种检查在临床设置的效用。

It is important to understand the pathophysiology of micro-vessels in atherosclerotic diseases, but there have been no laboratory examinations for it. We have developed a novel method where the blood levels of finger capillary arteries, which were moved during a non-invasive static pressurization of the skin, were measured quantitatively based on the hemoglobin absorption by light emitting diode. The velocity pressure index(VPI) assessed by this method showed a clinically acceptable reproducibility and coefficient of variation. The diabetic patients exhibited a significantly lower VPI level than controls. The VPI level was significantly and positively correlated with several atherosclerotic risk factors such as obesity and serum lipids in these patients. The diabetic and hypertensive patients with longer sleep duration showed a significantly lower VPI level than those with adequate sleep duration. These data suggest that the present method we developed may be useful to observe the pathophysiology of capillary arteries in lifestyle-related diseases. Further studies are warranted to establish the utility of this examination in the clinical setting.