Socio-behavioral development, very-early environments in genesis and its implications in health education

最近晚婚晚育的趋势可能会影响包括日本在内的发达国家的早期胚胎环境和基因组。晚婚晚育增加了受孕年龄，或者换句话说，导致卵子和精子年龄较大。这增加了自然受孕的挑战，相当一部分病例可能需要辅助生殖技术（ART）的帮助，如IVF（体外受精）和ICSI（胞质内精子注射）。晚期受孕和ART对行为发育的影响仍有待研究，因为它们在几十年内迅速流行。本研究使用多种方法，包括临床图表审查和队列调查的儿童出生/没有ART的帮助下检查的效果。在自闭症谱系障碍（ASD）儿童的家族性三重奏中，还测试了基因组DNA中的新生CNV（拷贝数变异）的患病率。分析正在进行中。迄今为止的临床图表审查表明，父母（父亲和母亲）的年龄较高可能与ASD和注意缺陷多动障碍的发展有关。

A recent trend of late marriage and late pregnancy might affect very early embryonic environments and genome in developed countries including Japan. The late marriage and pregnancy increase the age of conception, or in other words, cause conception by older egg and sperm. This increases the challenge in natural conception and a substantial portion of the cases may require help of assisted reproduction technology(ART), such as IVF(in-vitro fertilization) and ICSI(intra-cytoplasmic sperm injection). Effects of late conception and ART on behavioral development remain to be studied, because they prevailed rapidly in a couple of decades. This study examined the effects using several methods including a clinical chart review and a cohort survey of children born with/without the help of ART. Prevalence of de novo CNV(copy number variation) in genomic DNA was also tested in familial trios of autism spectrum disorder(ASD) children. Analyses are ongoing. The clinical chart review thus far suggests that higher ages in parents(both fathers and mothers) could be associated with the development of ASD and attention deficit hyperactivity disorder.