Local muscular steroidogenesis and exercise for anti-aging

性类固醇激素主要由卵巢、睾丸和肾上腺皮质产生和分泌，影响目标器官或组织的多种生理过程，如生殖器官、骨骼、肝脏、心脏、脉管系统、大脑和骨骼肌。先前，我们证明了骨骼肌能够局部合成循环脱氢表雄酮和雌激素。本研究旨在探讨生活方式相关疾病与局部骨骼肌和心肌肌少症的关系，并将其应用于抗衰老的运动治疗。我们的数据表明，局部甾体生成参与与年龄相关的生活方式相关的疾病和肌肉减少症，这一机制为运动疗法抗衰老预防提供了有益的信息。

Sex steroid hormones are mainly produced and secreted by the ovary, testis, and adrenal cortex and affect diverse physiological processes of target organs or tissues, such as reproductive organs, bones, liver, heart, vasculature, brain, and skeletal muscles. Previously, we demonstrated that skeletal muscles are capable of locally synthesizing circulating DHEA to testosterone and estrogen. This study examined association of life-style related diseases and sarcopenia in local skeletal and cardiac muscles and intended to apply it to exercise therapy for anti-aging. Our data demonstrated that local steroidogenesis is involved in age-related life-style related diseases and sarcopenia, suggesting that this mechanism provides beneficial information as a basic finding of the exercise therapy for anti-aging prevention.