Asymmetric Reactions Catalyzed by Metal Complexes with two Chiral Ligands

本课程组开发的手性Ru（II）和Ir（III）配合物有效催化1)醛和酮的不对称氰硅化反应，2)酮的不对称氢化反应，3)烯丙醇的不对称1,3-氢化物迁移。1)在底物与催化剂摩尔比（S/C）为10,000的条件下，反应的对映选择性高达99%。2)在高对映选择性条件下，制备了一系列其他方法难以制备的手性醇。其中一种反应已在手性药物的合成过程中商业化。3)在S/C为1000的条件下，对映体选择性可达98%

Chiral Ru(II) and Ir(III) complexes developped by our research groupi efficiently catalyzed 1) asymmetric cyanosilylation of aldehydes and ketones, 2) asymmetric hydrogenation of ketones, and 3) asymmetric 1,3-hydride migration of allylic alcohols : 1) Enantioselectivity as high as 99% in the reaction with a substrate-to-catalyst molar ratio (S/C) of 10,000 was achieved. 2) A series of chiral alcohols which is hardly prepared by the other methods was readily synthesized in high enantioselectivity. One of these ractions has been commercialized in the synthetic process of a chiral medicine. 3) The highest enantioselectivity of 98% in the reaction with an S/C of 1000 was achieved