Dynamics of histones during DNA replication, repair, and chromosome segregation
Dynamics of histones during DNA replication, repair, and chromosome segregation
批准号:
21370075
负责人:
SEKI Masayuki
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
核小体是由146 bp真核生物DNA包裹的组蛋白八聚体。组蛋白在DNA复制/修复过程中的动力学仍然难以捉摸。我们在这里提出,FACT通过促进有效的复制前核小体解体来促进DNA复制延伸。此外,我们表明,乙酰化组蛋白H3赖氨酸56是同源重组所需的。
英文摘要
The nucleosome is a histone octamer which is wrapped by 146 bp eukaryotic DNA. Dynamics of histones during DNA replication/repair remains elusive. We proposed here that FACT facilitates DNA replication elongation by promoting efficient pre-replicative nucleosome disassembly. Furthermore, we showed that acetylation of histone H3 on lysine 56 is required for homologous recombination.
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Analysis of DNA replication repression by excess Cdt1
过量 Cdt1 对 DNA 复制抑制的分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sasaki M, Hamada K, Kawahara K, Sasaki T, Maehama T, Suzuki A, 大隅達也, 牛田磨理]
通讯作者:
牛田磨理
Functional relationship between Claspin and Rad17
Claspin 和 Rad17 之间的功能关系
DOI:
10.1016/j.bbrc.2011.09.037
发表时间:
2011
期刊:
Biochem.Biophys.Res.Commun.
影响因子:
--
作者:
[Yoshimura, A., Akita, M., Hosono, Y., Abe, T., Kobayashi, M., Yamamoto, K.I., Tada, S., Seki, M., Enomoto, T.]
通讯作者:
T.
Global analysis of functional relationships between histone H2A and its variant Htz1
组蛋白 H2A 及其变体 Htz1 功能关系的整体分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[上野岳, 岡田裕介, 吉田隼人, 榎本武美, 堀越正美, 関政幸]
通讯作者:
関政幸
Global analysis of functional relationships between H2A and its variant Htz1
H2A及其变体Htz1功能关系的整体分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[上野岳, 岡田裕介, 吉田隼人, 榎本武美, 堀越正美, 関政幸]
通讯作者:
関政幸
In vivo analysis of histone variant exchange with H"B-H2A and H"B-Htzl fusion proteins
与 H"B-H2A 和 H"B-Htzl 融合蛋白的组蛋白变体交换的体内分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yu Nakahayashi, Lui Sato, Satoshi Kawashima, Gaku Ueno, Masayuki Seki, Masami Horikoshi]
通讯作者:
Masami Horikoshi
共 45 条
CPT (DNA topoisomerase I inhibitor) and DNA replication fork
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批准号:15K07009
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2015
-
负责人:SEKI Masayuki
-
依托单位:
Regulation of homologous recombination through sumoylation of Rad52
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批准号:19370073
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.81万
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财政年份:2007
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负责人:SEKI Masayuki
-
依托单位:
Study of genome instability syndromes
-
批准号:14380323
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:2002
-
负责人:SEKI Masayuki
-
依托单位:
Characterization of Proteins interacting with Werner syndrome gene product
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批准号:12672104
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
-
财政年份:2000
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负责人:SEKI Masayuki
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依托单位:
海外基金