Translational TGF-β Research for Diagnosis, Treatment, and Prevention of Cancer

转化生长因子-β相关分子TMEPAI、TSC22D4 （THG-1）和MafK被阐明启动致癌活性并促进恶性进展。对这些致癌基因功能的分子机制的研究为癌症的治疗和预防提供了新的靶分子。建立了TMEPAI、TSC22D4、MafK、Gpnmb等单克隆抗体。这些抗体将为这些工作在临床病理研究和癌症诊断方面的应用开辟道路。

Transforming growth factor-β-related molecules TMEPAI, TSC22D4 (THG-1), and MafK were elucidated to initiate carcinogenic activities and promote malignant progression. Study on the molecular mechanisms how these oncogenes functioning provided the novel target molecules for cancer treatment and prevention. We established monoclonal antibodies for TMEPAI, TSC22D4, MafK, Gpnmb and so on. These antibodies will open the application of these works for clinicopathological research and cancer diagnosis.