Functional analysis of oral sensation on the basis of signalplexes

脂肪是三种主要营养素之一，但它不是一种能激活五种基本味道之一（甜、苦、酸、盐和鲜味）的有味道的物质。然而，我们有经验，脂肪会大大改变菜肴的味道。瞬时受体电位M5（TRPM5）通道不是五种基本味觉的受体，但它在刺激甜味、苦味和鲜味的味觉蛋白偶联受体后被门控。我们分析了TRPM 5通道的电生理和药理学特性。TRPM5通道不被脂肪酸激活，但被脂肪酸调节。

Fat is one of the three major nutrients but it is not a sapid substance which activates one of the five basic tastes, sweet, bitter, sour, salt, and umami. However, we have experience that fat changes the taste of dishes largely. Transient receptor potential M5(TRPM5)channel is not a receptor of the five basic tastes but it is gated after stimulation of the gustducin-coupled receptors for sweet, bitter, and umami. We analyzed the electrophysiological and pharmacological properties of TRPM5 channel. TRPM5 channel was not activated by fatty acids, but modulated by fatty acids.