Crosstalk between the local temperature change inside single living cells and the cellular functions

本研究的目的是从微观角度阐明脑、心功能与温度之间的关系，其中[Ca^<2+>]与脑、心功能之间存在强耦合。我们首先专注于澄清单个活细胞的热特性。然后，局部温度梯度的效果进行了研究与使用分裂单个HeLa细胞。此外，分析了单个运动细胞对局部温度梯度和热脉冲的响应。同时，本研究还扩展到阐明心肌细胞振荡运动机制的研究。

The purpose of this study is to clarify the relationship between the temperature and the functions of the brain and the heart in which the [Ca^<2+>] strongly coupled with their function in the microscopic view point. We first focused on clarifying the thermal properties of single living cells. Then the effect of the local temperature gradient was studied with the use of dividing single HeLa cells. Furthermore, the response of the single motile cells to the local temperature gradient and the heat pulse was analyzed. In the meantime, the research was expanded to the studies to elucidate the mechanism of the oscillatory movement of the cardiac cell.