Development of fluorescent probes-dendrimer conjugates and their application for cell and in vivo imaging

在本研究中，我们发现在BODIPY中引入氨基导致其吸收光谱和荧光光谱发生了显著的变化，并基于这一发现成功地开发了几种荧光探针。此外，我们还合成了BDOIPYs和Frechet型树状大分子的共轭物，用于荧光成像。此外，我们发现一些具有近红外发射的发光镧系配合物可以引入活细胞，这取决于它们的天线部分的结构。

In this study, we discovered that introduction of amino groups to BODIPY resulted in remarkable alternation of its absorption and fluorescence spectra, and based on this finding, succeeded in the development of several fluorescent probes. Furthermore, we synthesized conjugates of BDOIPYs and Frechet type dendrimers for fluorescence imaging applications. Also, we found that some luminescent lanthanide complexes with near-infrared emission could be introduced to live cells, depending on the structure of their antenna moiety.