Peptidomics-based mining of novel antimicrobial peptides

最近，一家医院的耐药细菌问题日益严重。有效对抗这些细菌的候选之一是抗菌肽。本研究旨在利用肽组学分析从已鉴定的肽中发现新的抗菌肽。根据抗菌活性对其进行筛选，发现AMP-IBP5等2种新型抗菌肽。AMP-IBP5是一种分子内二硫化物连接的22位残基修饰肽。该肽具有比β-防御素-2更强的抗菌活性，可能成为新药的候选药物。

Recently, it has been an increasing problem of drug-resistant bacteria in a hospital. One of candidates effective against these bacteria is an antimicrobial peptide. This study was aimed at discovery of novel antimicrobial peptides from identified peptides using peptidomic analysis. We screened them based on antimicrobial activity and found two novel antimicrobial peptides including AMP-IBP5. AMP-IBP5 is an intramolecular disulfide-linked 22-residue amidated peptide. This peptide showed antimicrobial activity stronger than β-defensin-2 and could become candidates for new drugs.