Single molecular analysis of sumoylation-dependent chromatin remodeling factor

小泛素样修饰物(SUMO)与转录因子结合，抑制其靶基因的转录。虽然已经分离出了各种相扑结合转录因子，但相扑转录因子抑制转录的机制仍然很大程度上不清楚。为了了解相扑依赖转录抑制的机制，我们纯化了核受体的相互作用伙伴，并确定ARIP4为SNF2染色质重塑因子。

The small ubiquitin-like modifier (SUMO) conjugates transcription factors, and suppresses the transcription of their target genes. Although various SUMO-conjugated transcription factors have been isolated, mechanisms how sumoylated-transcription factors suppress transcription remain largely unknown. To understand mechanisms of SUMO-dependent transcriptional repression, we purified interacting partners for a nuclear receptor and identified ARIP4 known as a SNF2 chromatin-remodeling factor.