Mechanisms of the PCP signal transduction to bend neuroepithelial layer

神经管是中枢神经系统的前体，由神经板沿体轴弯曲而形成，尽管其潜在机制尚不完全清楚。我们发现，在构成神经板的神经上皮细胞的顶细胞-细胞接触部位，肌动球蛋白细胞骨架被激活并沿垂直于体轴的方向收缩，导致管状形成。此外，我们发现了一种新的信号通路，其中平面细胞极性信号调节弯曲神经板中肌动球蛋白的极化激活。

Neural tube is the precursor of the central nervous system, andformed by the bending of the neural plate along the body axis, although underlying mechanisms were not completely understood. We found that at the apical cell-cell contact sites of the neuroepithelial cells, which constitute neural plate, actomyosin cytoskeleton is activated and contracted in the direction perpendicular to the body axis, leading to a tube formation. Furthermore, we uncovered a novel signaling pathway in which the planar cell polarity signaling regulates the polarized activation of actomyosin in the bending neural plate.