Signaling pathway in amino acids mediated suppression of muscle proteolysis

本研究探讨了氨基酸作为肌管蛋白水解调节剂的作用。亮氨酸和谷氨酰胺抑制蛋白水解，同时还通过L-系统氨基酸转运蛋白（LAT 1）降低atrogin-1 mRNA的表达。氨基酸不激活AKT-FOXO信号通路，但抑制蛋白水解。因此，亮氨酸或氨基酸通过LAT 1而不是AKT-FOXO信号通路抑制肌肉蛋白水解的重要组成部分是其抑制肌肉蛋白降解的能力。

The present study addressed the role of amino acids as a regulator of proteolysis in myotubes. Leucine and glutamine suppressed proteolysis, while also decreasing expression of atrogin-1 mRNA through the L- system amino acid transporter (LAT1). Amino acids did not activate AKT-FOXO signaling pathway, but inhibiting proteolysis. Thus, an important component of muscle proteolysis inhibition by leucine or amino acids, through LAT1 but not AKT-FOXO signaling pathway, is its ability to suppress muscle protein degradation.