Research on the activation mechanism of volume-sensitive ion channels in neurons and glia

我们研究了中枢神经系统中对细胞体积、形状和命运影响最大的调节因子之一--体积敏感的外向整流(VSOR)阴离子通道的激活机制。在这一研究期间，我们特别发现了VSOR通道激活的一个基本机制，在主要的神经胶质细胞，星形胶质细胞，即使在周围组织发生微小损伤时也能高保真和确定地操作。

We investigated the activation mechanism of one of the most influential regulators of cell volume, shape and fate, the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system. Within this research period, we have found especially a fundamental mechanism of VSOR channel activation in the major glial cells, astrocytes, which would operate even in response to a minute damage happening in surrounding tissues with high fidelity and certainty.