Voluntary exercise linked with cerebral activation and baroreflex control of heart rate : its relation to motivated locomotion

[对照研究]我们连续测量了自由运动小鼠的大脑活动和HR的压力反射控制。我们发现，在小鼠的日常生活中，大脑激活抑制了心率（HR）的压力反射控制，在这些顺序反应之后，小鼠开始运动的概率比给定时间后高5倍，这表明大脑活动、HR的压力反射控制和自主运动之间存在密切联系。[V1a敲除研究]我们评估了抗利尿激素V1a受体在这些序列反应中的作用。我们在V1a受体敲除（KO）和野生型小鼠（WT）中持续测量上述变量。我们发现，在KO小鼠中，大脑皮层自愿激活对HR的压力反射控制的抑制被消除。此外，小鼠在大脑激活后开始移动的概率在KO中明显低于WT小鼠，因为HR的压力反射控制受到的抑制较少。这些结果表明，V1a受体通过抑制HR的压力反射控制，在大脑激活后开始自主运动中起重要作用。

[Control study] We continuously measured cerebral activity and baroreflex control of HR in freely moving control mice. We found that cerebral activation suppressed baroreflex control of heart rate (HR) in their daily life, and after these sequential responses, mice started to move at 5 times higher probability than after a given time, suggesting tight linkages between cerebral activity, baroreflex control of HR, and voluntary locomotion. [V1a knockout study] We assessed any role of vasopressin V1a receptor in these sequential responses. We continuously measured the variables mentioned above in V1a receptor knockout (KO) and wild-type mice (WT). We found that suppression of baroreflex control of HR in response to voluntary activation of the cerebral cortex was abolished in KO mice. Moreover, the probability that mice started to move after cerebral activation was markedly lower in KO than WT mice with less suppression of baroreflex control of HR. These results suggest that V1a receptor plays an important role in starting voluntary locomotion after cerebral activation through suppression of baroreflex control of HR.