Search of regulatory factors in neural glutathione concentration

谷胱甘肽是一种保护细胞的基本还原剂，在帕金森氏症等神经退行性疾病中被还原。神经元主要依赖细胞外半胱氨酸合成谷胱甘肽和一种被称为兴奋性氨基酸载体-1(EAAC1)的半胱氨酸转运体。我之前展示了GTRAP3-18(EAAC1的谷氨酸运输相关蛋白)与EAAC1相互作用，从而调节神经元谷胱甘肽水平。在这一时期，我指出了GTRAP3-18的磷酸化，这是寻找神经性谷胱甘肽浓度调节因素的关键信息。

Glutathione is an essential reductant which protects cells and is reduced in neurodegenerative disorders such as a Parkinson's disease. Neurons rely mainly on extracellular cysteine for glutathione synthesis and a cysteine transporter termed excitatory amino acid carrier-1 (EAAC1). I previously showed GTRAP3-18 (glutamate transport associated protein for EAAC1) to interact with EAAC1 and thereby regulate neuronal glutathione levels. In this time, I indicated the phosphorylation of GTRAP3-18, which is a key of information to search regulatory factors in neural glutathione concentration.