Comprehensive analysis base on the interaction between follicular lymphoma cells and follicular dendritic cells

为了阐明滤泡性淋巴瘤的发生机制，我们采用激光显微解剖和散弹枪蛋白质组学技术进行了综合蛋白检测分析。我们检测到大约2000种蛋白，其中GRHPR和PACAP分别在滤泡性淋巴瘤和非肿瘤性滤泡中检测到较多。这些基因在转录水平上均有过表达，在人体组织学样品中均有表达。本研究提示这些基因是滤泡性淋巴瘤发生的候选标记物，需要进一步的分子生物学和功能分析。

To elucidate mechanism of lymphomagenesis of follicular lymphoma, we examined comprehensive protein detection analysis using laser microdissection and shotgun proteomics. We detected approximately two thousand kinds of proteins, focused on GRHPR and PACAP, which detected frequently in follicular lymphoma, and non-neoplastic follicle respectively. These genes were over-expressed in transcriptional level and each protein expressions are affirmed in human histology sample. This study suggested these genes are the candidate marker in follicular lymphomagenesis, and further molecular biological and functional analyses are desirable.