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Cyclophilin A Mediates Pulmonary Vascular Remodeling by Rho-kinase Activation in Patients with Pulmonary Hypertension

Cyclophilin A Mediates Pulmonary Vascular Remodeling by Rho-kinase Activation in Patients with Pulmonary Hypertension
亲环蛋白 A 通过 Rho 激酶激活介导肺动脉高压患者的肺血管重塑
批准号:
21790698
负责人:
SATOH Kimio
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
翻译
我们检验了CyPA促进PAH患者肺血管重构的假设。我们的研究结果提供了直接的证据表明,CyPA/Rho激酶途径在人类PAH的发病机制中起着重要作用。
英文摘要
We tested the hypothesis that CyPA contributes to pulmonary vascular remodeling in PAH patients. Our results provide the direct evidence that the CyPA/Rho-kinase pathway plays an important role in the pathogenesis of PAH in humans.
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会议论文
DOI: 10.1161/atvbaha.110.214601
发表时间: 2011-05
期刊: Arteriosclerosis, thrombosis, and vascular biology
影响因子: --
作者: [Satoh K, Nigro P, Zeidan A, Soe NN, Jaffré F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC]
通讯作者: Berk BC
Cyclophilin A is an inflammatory mediator that promotes atherosclerosis.
亲环蛋白A是一种促进动脉粥样硬化的炎症介质。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Satoh K, et al., 佐藤公雄, 佐藤公雄, 佐藤公雄]
通讯作者: 佐藤公雄
DOI: 10.1253/circj.cj-10-0270
发表时间: 2010-09-01
期刊: CIRCULATION JOURNAL
影响因子: 3.3
作者: [Miura, Yutaka, Fukumoto, Yoshihiro, Shimokawa, Hiroaki]
通讯作者: Shimokawa, Hiroaki
DOI: 10.1084/jem.20101174
发表时间: 2011-01-17
期刊: The Journal of experimental medicine
影响因子: --
作者: [Nigro P, Satoh K, O'Dell MR, Soe NN, Cui Z, Mohan A, Abe J, Alexis JD, Sparks JD, Berk BC]
通讯作者: Berk BC
共 25 条
    Elucidation of the molecular mechanism of the multifaceted action of DOACs through cyclophilin A receptor
    • 批准号:
      15K15046
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2015
    • 负责人:
      SATOH Kimio
    • 依托单位:
    The development of novel tools for the diagnosis, prevention, and treatment of cardiovascular diseases based on Cyclophilin A
    • 批准号:
      24390193
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.4万
    • 财政年份:
      2012
    • 负责人:
      SATOH Kimio
    • 依托单位:
    New biomarker discovery for patients with pulmonary hypertension
    • 批准号:
      23659408
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      SATOH Kimio
    • 依托单位:
    海外基金