Control of intracellular signaling, involved in neuronal differentiation by using protein transduction domain and its application

由于中枢神经系统不能自然再生，因此通过移植神经元干细胞来再生受损的大脑/神经元是有希望的。在这项研究中澄清的主题是1 ;神经元分化的皮肤来源的前体细胞的潜力2 ;通过使用肽参与神经元分化的细胞内因子的控制。我们发现皮肤来源的前体细胞具有向神经元分化的能力，并且从分离到移植过程中不需要基因操作。设计了一种细胞毒性很小的肽段，引入调控细胞内信号转导的神经元分化诱导因子。人们认为，皮肤来源的前体细胞的利用是有用的，这是当时再生医学的唯一法则

As central nervous system is not regenerated naturally, reproduce of the damaged brain/neuron is expected by transplant of neuronal stem cells. Topics clarified in this study are 1 ; neuronal differentiation potential of skin-derived precursor cells 2 ; control of an intra-cellular factor involved in neuronal differentiation by using peptide. We identified the skin-derived precursor cells had neuronal differentiation ability and the advantage that there was no necessary of gene manipulation for the cells from isolation to transplant procedure. I designed the peptide, there was little cytotoxicity, which introduced to control intracellular signaling enrolled of neuronal differentiation inducing factor. It was thought that the utilization of the skin-derive precursor cells were useful as exclusive law of the regenerative medicine at this time