Functional analysis of cochlear outer hair cells in a dominant-negative connexin26 mutant mouse.

畸变产物耳声发射（DPOAEs）已被用于检查大鼠和沙鼠的听力发育。然而，没有关于小鼠听力开始时DPOAE测量的报道。组装市售组件并进行调整，以提供合适的探针麦克风和声音传递系统，用于测量发育中的C57 BL/6 J小鼠的DPOAE。并与听性脑干反应（ABR）结果进行比较。DPOAE从出生后11天开始在8 kHz下获得，从12天开始在20 kHz下获得，从13天开始在30 kHz下获得。成人样DPOAE模式在8和20 kHz，21天，28天，30 kHz。12 ~ 36 kHz的ABR阈值出现在11 ~ 12 d，14 d达到饱和。基于这些数据，小鼠中可测量的DPOAE的发作早于大鼠和沙鼠。在小鼠中，DPOAE的成熟开始于高频范围中的较低频率。此外，ABR阈值达到成熟早于DPOAE。

Distortion product otoacoustic emissions (DPOAEs) have been used to examine the development of hearing in the rat and gerbil. However, no reports of DPOAE measurement from the onset of hearing in mice are available. Commercially-available components were assembled and adapted to provide a suitable probe microphone and sound delivery system for measuring DPOAE in developing C57BL/6J mice. Furthermore, DPOAE data were compared with the findings of the auditory brainstem response (ABR). DPOAEs were obtained at 8 kHz from 11 days after birth, 20 kHz from 12 days, and 30 kHz from 13 days. Adult-like patterns of DPOAE were obtained 21 days at 8 and 20 kHz, and 28 days at 30 kHz. On the other hand, the ABR thresholds at 12 to 36 kHz appeared between 11 and 12 days and were saturated at 14 days. Based on these data, the onset of measureable DPOAEs in the mouse were earlier than in the rat and gerbil. The maturation of DPOAE in the mouse begins at a lower frequency in the high frequency range. In addition, the ABR threshold reached maturation earlier than DPOAE.