The effects of anesthetics on cortical spreading depression

皮质扩散性抑制(CSD)是一种短暂的神经元和神经胶质细胞的去极化和膜离子梯度的破坏，在大脑皮层缓慢传播。最近的临床和实验证据表明，CSD与偏头痛和神经元损伤状态的病理生理学有关。在本研究中，我们研究了四种不同的麻醉剂(异氟醚、异丙酚、右美托咪定、戊巴比妥)对应用KCl的动物模型中CSD易感性的影响。我们发现，与异丙酚和戊巴比妥相比，异氟醚和右美托咪定显著抑制CSD频率。此外，与异丙酚相比，右旋美托咪定和异氟醚有降低繁殖速度的趋势。这些数据可能有助于阐明CSD的发病机制，并建立偏头痛的新治疗方法。我们的数据还表明，这些麻醉剂可能在治疗上有益于预防不同神经血管疾病状态下的CSD。

Cortical spreading depression(CSD) is a transient neuronal and glial depolarization and disruption of membrane ionic gradients that propagates slowly across the cerebral cortex. Recent clinical and experimental evidence has implicated CSD in the pathophysiology of migraines and neuronal injury states. In the current study, we examined the influence of four different anesthetics(isoflurane, propofol, dexmedetomidine, pentobarbital) on CSD susceptibility in a KCl-application animal model. We found that isoflurane and dexmedetomidine significantly suppressed CSD frequency compared to propofol and pentobarbital. In addition, dexmedetomidine and isoflurane tended to reduce the propagation speed compared to propofol. These data may help to elucidate the mechanism of CSD and establish the new therapy for migraine. And our data also suggest that these anesthetics may be therapeutically beneficial in preventing CSD in diverse neurovascular disease states.