Expression of MUC1 splicing variants and its relationship with clinicopathological factors in oral squamous cell carcinoma.

本研究的目的是检测口腔鳞癌中粘蛋白MUC1的选择性剪接，并评估其与临床病理因素的关系。首先，我们通过免疫组织化学方法研究了切除肿瘤样本中膜粘蛋白的表达水平，发现MUC1和MUC4的异常表达是OSCC患者预后不良的独立预后因素。接下来，我们已经开始评估MUC1的每个剪接变体的表达水平，使用手术切除的口腔鳞状细胞癌标本。MUC1剪接变异体的表达水平和比例在每个标本中显示出巨大的变化。

The goal of this study was to detect alternative splicing of MUC1 mucin in oral squamous cell carcinoma and to evaluate its relationship with clinicopathological factors. First, we investigate the expression level of membranous mucin in the resected tumor samples by immunohistochemistry and found that aberrant expression MUC1 and MUC4 was an independent prognostic factor indicating poor prognosis in patients with OSCC. Next, we have started to evaluate the expression level of each splicing variant of MUC1, using the specimen from surgically resected oral squamous cell carcinoma. The expression level and proportion of MUC1 splicing variants showed a huge variety in each specimen.