Histological analysis of a molecule involved in development of function for eating and swallowing

神经周少突胶质细胞是一种无髓鞘少突胶质细胞，附着在不同神经区域的大神经元上。然而，人们对它们的细胞特征知之甚少。在这项研究中，我们检测了它们在小鼠大脑皮层中的细胞化学性质。几乎所有的神经节周围少突胶质细胞都表达胶质细胞专一性或富含胶质细胞的代谢酶。有趣的是，当大脑皮层发育和成熟时，它们更多地附着在谷氨酸能主神经元上。这些细胞化学特性表明，神经周少突胶质细胞的分化程度足以完成对相关主要皮质神经元的代谢支持。

Perineuronal oligodendrocytes are unmyelinating oligodendrocytes attaching to large neurons in various neural regions. However, little is known about their cellular characteristics. In this study, we examined their cytochemical properties in the mouse cerebral cortex. Almost all perineuronal oligodendrocytes expressed glia-specific or glia-enriched metabolic enzymes. Interestingly, they attached more to glutamatergic principal neurons, when the cerebral cortex develops and maturates. These cytochemical properties suggest that perineuronal oligodendrocytes are so differentiated as to fulfill metabolic support to the associating principal cortical neurons.