What is the role of glomeruloid vessels in glioblastoma?

肾小球血管（GV）是胶质母细胞瘤血管系统的标志。利用人胶质母细胞瘤冷冻切片，通过基因改变和免疫组化研究GV的作用。与小肿瘤血管和肿瘤细胞相比，与内皮细胞迁移相关的内啡肽在GV中表达上调。内啡肽与平滑肌细胞肌动蛋白一起定位于内皮细胞中，并与磷酸化的VEGFR2 （VEGF抗体作用标志物）和CD133（干细胞标志物）共定位。靶向内啡肽可能是一种有效的抗血管生成治疗损伤胶质母细胞瘤内皮干细胞的方法。

Glomeruloid vessel (GV) is a hallmark of glioblastoma vasculature. The role of GV was investigated with genetic alteration and immunohistochemistry using human glioblastoma frozen section. Endoglin, that is related to endothelial cell migration, was up-regulated in GV compared to small tumor vessels and tumor cells. Endoglin was localized in endothelial cells with smooth muscle cell actin and co-localized with phospholylated VEGFR2 (marker of VEGF antibody action) and CD133 (stem cell marker). Targeting endoglin has a possibility of a effective anti-angiogenic therapy damaging endothelial stem cell in glioblastoma.