Progress of anti-angiogenic therapy for brain tumors : new modality and resolution of the resistance

脑肿瘤抗血管生成治疗的进展：新模式和耐药性的解决

• 批准号: 21390403
• 负责人: TAKANO Shingo
• 金额: $ 11.23万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390403/
• 关键词: 膠芽腫; 血管新生; 腫瘍内皮細胞; ケモカイン; 抵抗性; 腫瘍微小環境; 神経膠腫; マイクロアレイ; siRNA; Notchシグナル; 光線力学療法; SDF-1; CXCR7; bevacizumab; low molecular weight heparin; metronomic treatment; 内皮細胞ワクチン

This study was designed to resolve the resistance and find a new generation anti-angiogenic therapy targeting glioblastoma endothelial cells.1. Solution of anti-angiogenic treatment for glioblastoma : Metronomic treatment using CPT-11 was effective to glioma growth without systemic side effect (J Neuro-oncology, 2010).2. Glioblastoma recurrence mouse model with continuous VEGF antibody treatment was established (Brain Tumor Pathol 2010, J Oncology 2010). With this model, Specific CXCR7 inhibitor, CCX771 and LMWH, antagnosit of SDF-1, inhibited recurrence after VEGF antibody treatment.3.Vaccination with tumor endothelial cells and tumor cells inhibited glioma growth strongly compared to vaccination with tumor cell alone.

本研究旨在解决胶质母细胞瘤的耐药问题，寻找新一代的以胶质母细胞瘤内皮细胞为靶点的抗血管生成药物.胶质母细胞瘤的抗血管生成治疗方案：使用CPT-11的Metronomic治疗对胶质瘤生长有效，无全身副作用（J Neuro-oncology，2010）.建立了连续VEGF抗体治疗的胶质母细胞瘤复发小鼠模型（Brain Tumor Pathol 2010，J Oncology 2010）。在此模型中，CXCR 7特异性抑制剂CCX 771和SDF-1的抑制剂LMWH均能抑制VEGF抗体治疗后的复发。3.与单独接种肿瘤细胞相比，肿瘤内皮细胞和肿瘤细胞联合接种对胶质瘤的生长有更强的抑制作用。

项目成果

Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation

• DOI: 10.1016/j.bbrc.2011.02.102
• 发表时间: 2011-03-25
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kaneko, Mika Kato;Tian, Wei;Kato, Yukinari
• 通讯作者: Kato, Yukinari

グリオーマ内の腫瘍細胞と内皮細胞の相互関係

胶质瘤内肿瘤细胞和内皮细胞之间的相互关系

• 发表时间: 2009
• 作者: 高野晋吾、大根田修;他
• 通讯作者: 他

悪性脳腫瘍に対する血管新生抑制療法

恶性脑肿瘤的抗血管生成治疗

• 发表时间: 2011
• 作者: Hanakita S;Iijima A;Ishikawa O;Kamada K;Saito N;高野晋吾
• 通讯作者: 高野晋吾

グリオーマにおける血管新生抑制療法の効果と耐性

胶质瘤抗血管生成治疗的效果和耐药性

• 发表时间: 2011
• 作者: 高野晋吾

Glioma immunotherapy with combined autologous tumor celland endothelial vaccination in vivo

体内联合自体肿瘤细胞和内皮疫苗接种的胶质瘤免疫治疗

• 发表时间: 2012
• 期刊: Neurol Med Chir (Tokyo)
• 作者: Sakamoto N;Uemae Y;Ishikawa E;Takano S;Nakai K;Yamamoto T;Zaboronok A;Matsumura A
• 通讯作者: Matsumura A