Transcription factor complex network and application in gene therapyfor patients with male infertility

如果自然妊娠不能发生，辅助生殖技术是最合适的处理方法，这种技术越来越多地用于治疗男性和女性不孕不育。然而，对于男性不育，体内受精比体外受精更好。在临床上，睾丸基因治疗未来可能对治疗男性不育有用，因为它可能促进男性不育患者的精子发生。在这项研究中，我试图进行基础研究，以实现男性不育的基因治疗。虽然在男性不育的基因治疗中还需要更多关于精子发生的分子基础的遗传信息，但这些信息可能会为临床治疗带来新的策略，基因治疗将为未来的男性不育患者提供巨大的好处。

Assisted reproductive technology is the most appropriate management if a natural pregnancy fails to occur, and this is increasingly used in the treatment of both male and female infertility. However, fertilization is better in vivo than in vitro for male infertility. Clinically, testicular gene therapy may be useful to treat male infertility in the future because it is possible to promote spermatogenesis in male infertility patient. In this study, I tried to perform basic research to realize the gene therapy for male infertility. Although more genetic information about the molecular basis of spermatogenesis will be needed to apply gene therapy for male infertility, these informations may lead to new strategies for the clinical management and gene therapy will provides great benefits for the patients with male infertility in the future.