Study for the mechanism in development of lifestyle-related disease by intake of dietary vegetable oil

本研究揭示了血浆脂质的增加参与了易卒中的自发性高血压大鼠（SHRSP）寿命缩短的部分机制，SHRSP是一种生活方式相关疾病的动物模型，喂食含有10 w/w%芥花油的饮食。这种增加，这是观察到的早期摄入期和之后，被抑制的氯贝特，一种过氧化物酶体增殖物激活受体α激动剂的组合管理。此外，死亡和慢性肾病的发生率也因给药而降低。需要进一步的研究来阐明菜籽油摄入引起的短寿命的机制，包括氯贝丁酯的详细作用模式。

This study revealed that increase in plasma lipids was involved in a part of mechanism in the shortening of lifespan of stroke prone spontaneously hypertensive rats (SHRSP), one animal model of lifestyle-related disease, fed diet containing 10 w/w% canola oil. This increase, which was observed on and after the early intake period, was inhibited by the combined administration of clofibrate, a PPAR alpha agonist. Additionally, incidences of death and chronic nephropathy were attenuated by the administration. Further studies are needed to elucidate the mechanism of short lifespan induced by canola oil intake, involving the detailed mode of action of clofibrate.