Development of a tumor diagnosis system using novel immuno-PET/MRI probe

在本研究中，我们分离和纯化了一种肿瘤血管内皮细胞特异性单抗作为肿瘤靶向工具。该单抗经RI标记后可作为肿瘤显像剂。此外，我们还尝试使用该抗体作为免疫-PET/MRI的成像探针。因此，我们建立了聚乙二醇化的金/氧化铁磁性纳米粒子的制备工艺，这种磁性纳米粒子在聚乙二醇链的顶端修饰了单抗，作为一种新型的磁共振显像剂。

In this study, we isolated and purified a tumor vascular endothelial cell specific monoclonal antibody as tumor targeting device. This monoclonal antibody which was labeled by RI functioned as a tumor imaging probe. Furthermore, we tried development as an imaging probe for immuno-PET/MRI using this antibody. As a result, we have established the technology to produce the PEGylated gold/iron oxide magnetic nanoparticles, which has modified monoclonal antibody on the tip of PEG chain, as a novel magneticresonance imaging agent.